Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception
نویسندگان
چکیده
منابع مشابه
Involvement of nuclear factor kappa B in the maintenance of persistent inflammatory hypernociception
The pathophysiology of chronic inflammatory pain remains poorly understood. In this context, we developed an experimental model in which successive daily injection of prostaglandin E2 (PGE2) for 14days into rat hind paws produces a persistent state of hypernociception (i.e. decrease in mechanical nociceptive threshold). This state persists for more than 30days after discontinuing PGE2 injection...
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Oxymatrine, a potent monosomic alkaloid extracted from Chinese herb Sophora japonica (Sophora flavescens Ait.). possesses anti-inflammatory activittyes. This study was designed to investigate the effects of oxymatrine on nuclear factor–kappa B (NF-κB) and mitogen-activated protein kinase (MAPK)-dependent inflammatory responses in lipopolysaccharide (LPS)-activated microglia. In this paper, BV2...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2015
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2015.04.005